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Even Mild Gestational Diabetes Benefits From Treatment

A clinical trial from the Eunice Kennedy Shriver National Institute of Child Health and Human Development shows that diet intervention and frequent glucose monitoring benefitted both moms with mild gestational diabetes and their babies.

When a pregnant woman is diagnosed with gestational diabetes, diet intervention and glucose monitoring, and in some instances, insulin are prescribed but for mild cases there was some concern that these treatments could present a risk to moms and their babies.

This study proves that even when women have a mild cases of gestational diabetes, treating the diabetes does not pose a risk and benefits moms and babies.

More on gestational diabetes from your diabetes guide…

Even Mild Gestational Diabetes Benefits From Treatment originally appeared on About.com Diabetes on Wednesday, September 30th, 2009 at 22:39:35.

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Women with Diabetes at Higher Risk for Atrial Fibrillation

A recent study from Kaiser Permanente Center for Health Research shows that women who have diabetes have a 26% increase in risk for developing atrial fibrillation (AF). AF is a serious heart arrhythmia which can lead to stroke and other cardiac problems.

In the study, it was discovered that women with diabetes had the same risk for AF as men who did not have diabetes. Men with diabetes have a higher incidence of AF than men without diabetes, but diabetes does not appear to be the cause of AF in men. It was shown in this study, however, that diabetes does raise the risk of AF in women.

Women with Diabetes at Higher Risk for Atrial Fibrillation originally appeared on About.com Diabetes on Wednesday, September 30th, 2009 at 22:17:26.

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Treating Mild Gestational Diabetes Cuts Some Risks, but Not Worst (CME/CE, with video)

Treatment of mild gestational diabetes may reduce cesarean section rates and other maternal and fetal complication risks, but won’t prevent the most serious of outcomes, researchers found.

Stem Cell Success Points To Way To Regenerate Parathyroid Glands

An early laboratory success is taking researchers a step closer to parathyroid gland transplants that could one day prevent a currently untreatable form of bone loss associated with thyroid surgery.

EASD: Insulin Analogues, Cancer Linked, but No Causality Shown

VIENNA (MedPage Today) — Patients taking insulin-based drugs for diabetes appear prone to increased rates of cancer diagnosis, but there appears to be no special risk for insulin glargine (Lantus) compared with other insulins, researchers said here.

RAGE, glomerulosclerosis and proteinuria: Roles in podocytes and endothelial cells.

Publication Date: 2009 Sep 25 PMID: 19783154
Authors: D’Agati, V. – Yan, S. F. – Ramasamy, R. – Schmidt, A. M.
Journal: Trends Endocrinol Metab

The multi-ligand Receptor for Advanced Glycation Endproducts (RAGE) is expressed in podocytes and endothelial cells in the human and murine glomerulus. Although present at low levels in homeostasis, RAGE expression is increased during disease. Pharmacological antagonism of RAGE or its genetic deletion imparts marked protection from podocyte effacement, albuminuria and glomerular sclerosis in disease models. In human subjects, associations between specific genetic polymorphisms of RAGE and levels of soluble forms of RAGE are linked to disease states in the kidney. In this review, we summarize the evidence from mouse to man, linking RAGE to the pathogenesis of nephropathy.

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Plasma Membrane Estrogen Receptors.

Publication Date: 2009 Sep 22 PMID: 19783454
Authors: Levin, E. R.
Journal: Trends Endocrinol Metab

It is now firmly established that estrogen and all sex steroid receptors exist in discrete cellular pools outside the nucleus. Estrogen receptors (ER) have been localized to the plasma membrane where both ERalpha and ERbeta function in a wide variety of cells and organs. ERs have also been found in discrete cytoplasmic organelles including mitochondria and the endoplasmic reticulum. In ligand-dependent fashion, each ER pool contributes to the overall, integrated effects of estrogens producing biological outcomes. This review highlights the recent work establishing new roles and targets of membrane ER signaling. Such actions include prevention of vascular injury or cardiac hypertrophy, sexual behavior and pain perception mediated through the central nervous system, osteoblast survival, and fluid resorption in the colon.

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Study Shows AFRESA(R) Provides Rapid Suppression Of Endogenous Glucose Production In Diabetes Patients

AFRESA® (insulin human [rDNA origin]) Inhalation Powder is a well-tolerated, ultra rapid acting insulin able to more closely replicate normal glucose suppression than currently available insulins, according to data presented at the 45th Annual Meeting of the European Association for the Study of Diabetes.

In The Prevention Of Heart Failure, Fish Does Not Take A Major Role

‘No major role for fish’ in the prevention of heart failure; only a possible beneficial effect in those with diabetes The consumption of fish has no major role in the prevention of heart failure, according to results from a large prospective population study.

Stem Cell Success Could Help Regenerate Parathyroids

An early laboratory success is taking University of Michigan researchers a step closer to parathyroid gland transplants that could one day prevent a currently untreatable form of bone loss associated with thyroid surgery. The scientists were able to induce embryonic stem cells to differentiate into parathyroid cells that produced a hormone essential to maintaining bone density.