Incidence and risk factors of falling in ambulatory patients with rheumatoid arthritis: a prospective 1-year study. - Hayashibara M, Hagino H, Katagiri H, Okano T, Okada J, Teshima R.
February 8, 2010 – 2:52 pm A prospective 1-year study showed that fall incidence was 50% in women with rheumatoid arthritis. Multivariate analysis identified swollen joint count, use of antihypertensives or diuretics, one-leg standing time, and sway area measured by stabilometer ... (Source: SafetyLit: All (Unduplicated))MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
Molecular Therapies for Systemic Lupus Erythematosus: Clinical Trials and Future Prospects
February 8, 2010 – 11:04 am Exploring new pharmacological options and therapeutic avenues for lupus: a focus on non-antibody molecular strategies. Arthritis Research & Therapy (Source: Medscape Today Headlines)Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk of bias assessment
February 7, 2010 – 11:00 pm A food supplement containing fish oils, urtica dioica, Zinc, and Vitamin E (Phytalgic(R)) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for three months and according to the authors has a very large clinical effect, considerably larger than any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above .5 is rarely seen. Despite our concern about the trial registration taking place after the study was completed, and the likelihood that patients would note the taste of fish, thus leading to detection bias, we consider these data promising although with a high risk of bias. (Source: Arthritis Research and Therapy)Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression
February 7, 2010 – 11:00 pm Conclusions: These results suggest that abnormal production of leptin by OA Ob could be responsible, in part, for the elevated levels of ALP, OC, collagen type 1 and TGF-beta1 observed in these cells compared to normal. Leptin also stimulated cell proliferation, and Erk 1/2 and p38 signaling. Taken together, these data suggest leptin could contribute to abnormal osteoblast function in OA. (Source: Arthritis Research and Therapy)Identification of a Novel Candidate Locus for Juvenile Idiopathic Arthritis at 14q13.2 in the Latvian Population by Association Analysis with Microsatellite Markers
February 7, 2010 – 2:34 pm DNA and Cell Biology , Vol. 0, No. 0. (Source: DNA and Cell Biology)Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis? A 15-year follow-up.
February 7, 2010 – 12:08 pm Conclusions: Our results indicate that most of the patients with long-standing RA require continuous DMARD treatment. If the treatment is discontinued, patients should be followed-up closely and DMARDs readministered without delay if the disease flares up. PMID: 20132065 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)Time to methotrexate treatment in patients with rheumatoid arthritis referred to hospital.
February 7, 2010 – 12:08 pm Conclusions: The data suggest that reduction in the time to start MTX treatment after referral to hospital could be improved, especially among patients with less severe symptoms. However, our results show that treatment practice in recent years has changed towards an earlier MTX treatment start. PMID: 20132066 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis.
February 7, 2010 – 12:08 pm Conclusion: The present study demonstrated that T helper cells from RA patients display a significantly altered expression profile of Notch receptors and enhanced activation of Notch signalling compared with HC. PMID: 20132067 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)Cystatin C is a sensitive marker for detecting a reduced glomerular filtration rate when assessing chronic kidney disease in patients with rheumatoid arthritis and secondary amyloidosis.
February 7, 2010 – 12:08 pm Conclusions: Serum cysC can identify a reduced GFR more accurately than sCr-eGFRs. Serum cysC >1.09 mg/L (i.e. eGFR(Rule)<60 mL/min/1.73 m(2)) could be a marker of a reduced GFR, and serum cysC >1.365 mg/L would strongly suggest a reduced GFR in patients who have RA with secondary amyloidosis. PMID: 20132068 [PubMed - in process] (Source: Scandinavian Journal of Rheumatology)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.